Reported side effects include lethargy, which can range from mild to severe, increased blood pressure, bloating, joint pains, cramps, mild headaches, insomnia, aggressiveness, and irritability.
Many users also find that methyl 1-test decreases appetite, which can be harmful or beneficial depending on one's goals. These side effects can be reduced by lowering dosage or taking smaller doses more frequently.
Another concern with methyl 1-test (and methylated steroids in general) is hepatotoxicity. Other substances that are toxic to the liver (such as alcohol) should be avoided to avoid placing extra stress on the liver. Milk thistle, alpha lipoic acid, and N-acetyl-cysteine are commonly recommended to help protect the liver.
The 17-epimers of the anabolic steroids bolasterone ( I ), 4-chlorodehydromethyltestosterone ( II ), fluoxymesterone ( III ), furazabol ( IV ), metandienone ( V ), mestanolone ( VI ), methyltestosterone ( VII ), methandriol ( VIII ), oxandrolone ( IX ), oxymesterone ( X ), oxymetholone ( XI ), stanozolol ( XII ), and the human metabolites 7α,17α-dimethyl-5β-androstane-3α,17β-diol ( XIII ) (metabolite of I ), 6β-hydroxymetandienone ( XIV ) (metabolite of V ), 17α-methyl-5β-androst-1-ene-3α,17β-diol ( XV ) (metabolite of V ), 3'-hydroxystanozolol ( XVI ) (metabolite of XII ), as well as the reference substances 17β-hydroxy-17α-methyl-5β-androstan-3-one ( XVII ), 17β-hydroxy-17α-methyl-5β-androst-1-en-3-one ( XVIII ) (also a metabolite of V ), the four isomers 17α-methyl-5α-androstane-3α,17β-diol ( XIX ) (also a metabolite of VI , VII , and XI ), 17α-methyl-5α-androstane-3β,17β-diol ( XX ), 17a-methyl-5β-androstane-3α,17β-diol ( XXI ) (also a metabolite of V, VII , and VIII ), 17α-methyl-5β-androstane-3β,17β-diol ( XXII ), and 17β-hydroxy-7α, 17α-dimethyl-5β-androstan-3-one ( XXIII ) were synthesized via a 17β-sulfate that spontaneously hydrolyzed in water to several dehydration products, and to the 17α-hydroxy-17β-methyl epimer. The 17β-sulfate was prepared by reaction of the 17β-hydroxy-17a-methyl steroid with sulfur trioxide pyridine complex. The 17β-methyl epimer s are eluted in gas chromatography as trimethylsilyl derivatives from a capillary SE-54 or OV-1 column 70–170 methylen units before the corresponding 17α-methyl epimer. The electron impact mass spectra of the underivatized and trimethylsilylated epimers are in most cases identical and only for I, II , and V was a differentiation between the 17-epimers possible. 1 H nuclear magnetic resonance (NMR) spectra show for the 17β-methyl epimer a chemical shift for the C-18 protons (singlet) of about ppm (in deuterochloroform) to a lower field. 13 C NMR spectra display differences for the 17-epimeric steroids in shielding effects for carbons 12–18 and 20. Excretion studies with I–XII with identification and quantification of 17-epimeric metabolites indicate that the extent of 17-epimerization depends on the A-ring structure and shows a great variation for the different 17α-methyl anabolic steroids.
It does not aromatize, however it is possible that methylepitiostanol may offset estrogen and testosterone from SHBG thus increase the risk of gyno for certain individuals with high SHBG levels. Gyno symptoms from this compound may also be a result of this compounds inability to form a potent androgen such as DHT (to antagonize the effects of estrogen). However, in other cases methylepitiostanol can be used to prevent or reduce gynecomastia from an estrogenic steroid by acting as an aromatase inhibitor to keep estrogen down.
It is a DHT derivative with a fairly moderate androgenic value so the chances of hair loss may be increased in certain sensitive users. Swelling of the prostate may also become an issue. The powerful estrogen suppressing action of this steroid and its 17aa stucture will cause it to negatively influence the cholesterol profile by lowering HDL and increasing LDL. It has also been reported to cause stiff joints, possibly related to its suppressive effect on estrogen levels.