With the increasing prevalence of allergic conditions, many studies have examined risk factors for allergies and how to modify these to potentially prevent allergies. The development of allergies results from a complex interplay between a person’s genetic make-up (genotype) and its interaction with the environment (phenotype). Having family members with allergic conditions increases the risk of allergy. Numerous environmental influences may also affect the development of allergy, such as breastfeeding, cesarean sections, diet during pregnancy, vitamin D levels, use of antibiotics, use of probiotics, animal exposures, pollutant exposure, and diet during infancy. Of all the factors studied to date, it appears that introducing highly allergic foods into the child’s diet before one year of age may decrease the risk of food allergy, particularly peanut allergy. Allergen immunotherapy (allergy shots) have also been shown to decrease the risk of developing future environmental allergies and asthma. Finding additional ways to prevent allergic conditions remains an active area of research.
In addition to allergic reactions, there are various types of idiosyncratic adverse reactions to NSAIDs that are presumed or known to involve other types of immune mechanisms. These include, but are not limited to, aseptic meningitis, hypersensitivity pneumonitis, thrombocytopenia, interstitial nephritis, erythema multiforme, fixed drug eruptions, toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema nodosum, maculopapular eruptions, and bullous leukocytoclastic vasculitis [ 1 ]. These types of reactions are discussed in various topic reviews. (See "Nonselective NSAIDs: Overview of adverse effects" and "Drug eruptions" and "Stevens-Johnson syndrome and toxic epidermal necrolysis: Pathogenesis, clinical manifestations, and diagnosis" .)
Kids With Food Allergies
A Division of the Asthma and Allergy Foundation of America
4259 W Swamp Rd, Suite 408, Doylestown, PA 18902
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