Corticosteroids gland

Catecholamines are produced in chromaffin cells in the medulla of the adrenal gland, from tyrosine , a non-essential amino acid derived from food or produced from phenylalanine in the liver. The enzyme tyrosine hydroxylase converts tyrosine to L-DOPA in the first step of catecholamine synthesis. L-DOPA is then converted to dopamine before it can be turned into noradrenaline. In the cytosol , noradrenaline is converted to epinephrine by the enzyme phenylethanolamine N-methyltransferase (PNMT) and stored in granules. Glucocorticoids produced in the adrenal cortex stimulate the synthesis of catecholamines by increasing the levels of tyrosine hydroxylase and PNMT. [4] [13]

Long-acting corticosteroids improve lung function by suppressing inflammation in the respiratory passages and help reduce the need for oral medication. Types of long-acting corticosteroids and their usual daily dosages pinclude the following:

  • Aerospan (flunisolide HFA)—2 inhalations 2x/day
  • Alvesco (ciclesonide)—1-2 inhalations 2x/day
  • Asmanex Twisthaler (mometasone)—1 inhalation 2x/day or 2 inhalations 1x/day
  • Flovent HFA (fluticasone)—1-4 inhalations 2x/day
  • Pulmicort Flexhaler (budesonide)—1-2 inhalations 2x/day
  • QVAR (beclomethasone)—1-4 inhalations 2x/day

Corticosteroids gland

corticosteroids gland

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