Certain drugs such as troleandomycin (TAO), erythromycin ( Ery-Tab , EryPed 200), and clarithromycin ( Biaxin ) and ketoconazole ( Nizoral ) can reduce the ability of the liver to metabolize (breakdown) corticosteroids and this may lead to an increase in the levels and side effects of corticosteroids in the body. On the other hand, phenobarbital, ephedrine , phenytoin ( Dilantin ), and rifampin ( Rifadin , Rimactane ) may reduce the blood levels of corticosteroids by increasing the breakdown of corticosteroids by the liver. This may necessitate an increase of corticosteroid dose when they are used in combination with these drugs.
No evidence exists that epiphyses close prematurely in very young oral contraceptive pill users, and bone density is well preserved. 4 , 25 Furthermore, many teenage girls appreciate the noncontraceptive benefits of having shorter menses, more regular periods and relief from dysmenorrhea. Counseling that these benefits evaporate when pills are discontinued helps to encourage compliance when the primary purpose of oral contraceptive pill use is to relieve a physiologic condition. Acne and hirsutism may be improved with the use of more estrogenic formulations and the newest progestin formulations.
Many people with chronic lung disease periodically require a short-term burst of steroid pills or syrups to decrease the severity of acute attacks and prevent an emergency room visit or hospitalization. A burst may last two to seven days and may not require a gradually decreasing dosage. For others, a burst may need to continue for several weeks with a gradually decreasing dosage. You may experience a few mild side effects such as increased appetite, fluid retention, moodiness and stomach upset. These side effects are temporary and typically disappear after the medicine is stopped.