Elimination: The elimination rate of intravenous administered fluticasone propionate is linear over the 250-1000mcg dose range and are characterized by a high plasma clearance (CL=/min). Peak plasma concentrations are reduced by approximately 98% within 3-4 hours and only low plasma concentrations were associated with the terminal half-life. The renal clearance of fluticasone propionate is negligible (<%) and less than 5% as the carboxylic acid metabolite. The major route of elimination is the excretion of fluticasone propionate and its metabolites in the bile.
Simple non-pharmacological and avoidance measures do help. For example, a simple saline (salt water) nasal douche or lavage is effective. Saline and sea water nose sprays (Sterimar) help flush pollen grains off the nasal mucosal and improve nasal patency. While a little Vaseline applied to the lower nostrils on cotton bud is both soothing and protective. Wrap-around sunglasses are helpful and occasionally a face and nose mask may be necessary. Monitoring of pollen forecasts and remaining indoors during mid morning and early evening (when pollen counts peak) will help. Taking an immediate shower and change of clothing after extended outdoor exposure will reduce pollen levels transferred indoors. Additional prophylactic medication may need to be taken on days when pollen counts are excessively high. When travelling by car, be sure to close the windows and put on the air conditioner to filter out pollen. Special pollen arresting filters and ionisers in the home are expensive and often ineffective.