Progestin based steroids

In the estrogen alone substudy of the Women's Health Initiative Memory Study (WHIMS), a substudy of WHI, a population of 2,947 hysterectomized women, 65 to 79 years of age, was randomized to receive daily conjugated estrogens (CE mg) or placebo. After an average follow-up of years, the relative risk (CE versus placebo) of probable dementia was (95 percent CI, -). The absolute risk of developing probable dementia with estrogen alone was 37 versus 25 cases per 10,000 women-years compared to placebo.

Our current understanding of adrenal function is still at its infancy at best. It is therefore very difficult for any health professional to have a good grasp of the Adrenal Fatigue condition from a purely pathological and physiological perspective. The number of physicians with true expertise in advanced Adrenal Fatigue is very small. Those who are good in this gain their expertise not from textbooks, but from years of clinical experience. There is no short cut, because text-book cases are few and far between. Because the full recovery cycle can take years to complete in severe cases, practitioners with little experience will find it hard to handle cases other than the most mild and straight forward ones.

Not only does progesterone help prevent further damage, it has also been shown to aid in neuroregeneration . One of the serious effects of traumatic brain injury includes edema. Animal studies show that progesterone treatment leads to a decrease in edema levels by increasing the concentration of macrophages and microglia sent to the injured tissue. [63] [66] This was observed in the form of reduced leakage from the blood brain barrier in secondary recovery in progesterone treated rats. In addition, progesterone was observed to have antioxidant properties, reducing the concentration of oxygen free radicals faster than without. [64] There is also evidence that the addition of progesterone can also help re myelinate damaged axons due to trauma, restoring some lost neural signal conduction. [64] Another way progesterone aids in regeneration includes increasing the circulation of endothelial progenitor cells in the brain. [67] This helps new vasculature to grow around scar tissue which helps repair the area of insult.

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Progestin based steroids

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