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Fifth, although trans women dissociate less when they take estrogen, trans men dissociate less when they take testosterone. I can’t find whether testosterone has similar NMDA-promoting properties in the brain, although it sometimes gets aromatized to estrogen so that might be relevant. Also, I’ve never heard of any trans woman taking testosterone or trans man taking estrogen. If that makes dissociation worse – and from the psychosocial perspective it probably should – then that would be a strike against this theory.