Like other topical corticosteroids, clobetasol propionate has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A 2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor , arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
Weaker topical steroids are utilized for thin- skinned and sensitive areas, especially areas under occlusion, such as the armpit, groin, buttock crease, breast folds. Weaker steroids are used on the face, eyelids, diaper area, perianal skin, and intertrigo of the groin or body folds. Moderate steroids are used for atopic dermatitis , nummular eczema , xerotic eczema , lichen sclerosis et atrophicus of the vulva , scabies (after scabiecide) and severe dermatitis . Strong steroids are used for psoriasis , lichen planus , discoid lupus , chapped feet, lichen simplex chronicus , severe poison ivy exposure, alopecia areata , nummular eczema, and severe atopic dermatitis in adults. 
My doctor sent me to a dermatologist-he took one glance and declared I had perioral dermatitis. Put me on a course of antibiotics. It would clear up, and then start coming back. The dermatologist keep saying don’t worry we have more antibiotics to try. I tried 3 different kinds with the same results and decided to go off completely. Went to a naturopath-was prescribed a bunch of extremely expensive stuff-didn’t work. Decided to live with PD. Tried every natural remedy known to man. Would flare up and subside, but never go away. Then I became pregnant and after my baby was born I decided I had to do something about this as the flareups were getting worse and leaving scars. During my pregnancy I’d met a girl in my friends clothing shop who had claimed to have had PD, even though her skin was beautiful, and said she had gone to so and so at WellSpring health Vitamin shop and taken what he prescribed. Now I had a Homeopath for a sister-in-law who couldn’t help me and also a good friend who worked in a vitamin store who had not been able to help me either. I was decided it was worth it anyway. This person listened to me, asked me my blood type and heard all my symptoms. He said I need to be on high doses of B5-pantothenic acid. Combined with New Chapter breast feeding formula vitamins 3 x’s a day, fish oil, high dose probiotics and magnesium plus NAC-N-acetyl Cysteine. So we are taking about 1000mgs of B5 3x’s a day. NAC before bed. Magnesium 3 x’s a day, probiotics 3 x’s a day, fish oil once and breast feeding vitamins 3x’s a day. Well, within 12 hrs that familiar burning inflammatory skin feeling went away. Then 24 hrs later the PD started to fade, just fade away. Within a week-it was gone. I was on this cycle of vitamins for 6 months-then lowered the doses of B5. Now, years later, I take this combo to maintain when I’m feeling stressed or I notice one or two tiny red bumps-which always appear around my period.