METHYL PREDNISOLONE : Decreases effect of anticholinesterases in myasthenia gravis. May decrease the hypoglycaemic effects of antidiabetic agents. Decreases serum concentrations of salicylates. Increased hypokalemic effects of potassium-depleting diuretics (thiazides or furosemide), amphotericin B, bronchodilator therapy with xanthines or ß2 agonists. Increase incidence of GI bleeding and ulceration with NSAIDs. May increase the anticoagulant effects of warfarin. Decreased levels/effects with CYP3A4 inducers (aminoglutethimide, carbamazepine, nafcillin, nevirapine, phenobarbital, phenytoin, and rifamycins). Increased levels/effects with CYP3A4 inhibitors (azole antifungals, clarithromycin, diclofenac, doxycycline, erythromycin, imatinib, isoniazid, nefazodone, nicardipine, propofol, protease inhibitors, quinidine, telithromycin, and verapamil). May decrease the effects of vaccines (dead organism) or increase the risk of vaccinal infection (live organism). Antacids and bile sequestrants may decrease the absorption of corticosteroids, separate admin by 2 hr. Increased risk of myopathy with neuromuscular-blocking agents, tendinopathies with fluoroquinolones.
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Arthritis : Arthritis is a form of joint disorder that involves inflammation of one or more joints. There are over 100 different forms of arthritis. The most common form, osteoarthritis (degenerative joint disease), is a result of trauma to the joint, infection of the joint, or age. Other arthritis forms are rheumatoid arthritis, psoriatic arthritis, and related autoimmune diseases. Septic arthritis is caused by joint infection.
Aceclofenac, Abatacept, Adalimumab, Celecoxib, Cyclosporine, Diclofenac, Diflunisal, Etoricoxib, Flurbiprofen, Hydrocortisone, Hydroxychloroquine, Ibuprofen, Mefenamic Acid, Meloxicam, Sulindac and Tenoxicam
Bronchitis : Bronchitis is an inflammation of the mucous membranes of the bronchi (the larger and medium-sized airways that carry airflow from the trachea into the more distal parts of the lung parenchyma) Treatment Conventional treatment for acute bronchitis may consist of simple measures such as getting plenty of rest, drinking lots of fluids, avoiding smoke and fumes, and possibly getting a prescription for an inhaled bronchodilator and/or cough syrup. In some cases of chronic bronchitis, oral steroids to reduce inflammation and/or supplemental oxygen may be necessary.
Edema : Edema is swelling caused by excess fluid trapped in your body's tissues. Although edema can affect any part of your body, it's most commonly noticed in your hands, arms, feet, ankles and legs. Edema can be the result of medication, pregnancy or an underlying disease — often heart failure, kidney disease or cirrhosis of the liver. Taking medication to remove excess fluid and reducing the amount of salt in your food usually relieves edema. When edema is a sign of an underlying disease, the disease itself requires separate treatment. There are many types of edema. The most common ones are: ? Peripheral edema - in the feet (pedal edema), ankles, legs, hands and arms. ? Cerebral edema - in and around the brain (cerebral edema). ? Eye edema - in and around the eyes, . macular edema, corneal edema, periorbital edema (puffiness around the eys. Macular edema is a serious complication of diabetic retinopathy. ? Signs and symptoms of edema include: • Swelling or puffiness of the tissue directly under your skin • Stretched or shiny skin • Skin that retains a dimple after being pressed for several seconds • Increased abdominal size Medications : • NSAIDs (ibuprofen, naproxen) • Calcium channel blockers • Corticosteroids (prednisone, methylprednisolone) • Pioglitazone and rosiglitazone • Pramiprexole